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College of Pharmacy

Dr. Igor Roninson

COBRE Center for Targeted Therapeutics


Through pilot projects and collaborative studies, our research at the Center for Targeted Therapeutics encompasses targeted therapeutics for multiple diseases. Explore our index of publications.

Title Authors Journal Year Keywords
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Mitochondrial might: powering the peripartum for risk and resilience Gorman-Sandler E, Wood G, Cloude N, Frambes N, Brennen H, Robertson B, Hollis F Frontiers in Behavioral Neuroscience 2023  
Hippo Signaling Mediates TGFβ-Dependent Transcriptional Inputs in Cardiac Cushion Mesenchymal Cells to Regulate Extracellular Matrix Remodeling Chakrabarti M, Chattha A, Nair A, Jiao K, Potts JD, Wang L, Branch S, Harrelson S, Khan S, Azhar M Journal of Cardiovascular Development and Disease 2023  
Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus Naderi A, Liles K, Burns T, Chavez B, Huynh-Dam KT, Kiaris H BMC Genomics 2023  
Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide Li Y, Eans SO, Ganno-Sherwood M, Eliasof A, Houghten RA, McLaughlin JP Molecules 2023  
Therapeutics to Treat Psychiatric and Neurological Disorders: A Promising Perspective from Algerian Traditional Medicine Larit F, León F Plants (Basel) 2023  
The O-GlcNAc dichotomy: when does adaptation become pathological? Costa TJ, Wilson EW, Fontes MT, Pernomian L, Tostes RC, Wenceslau CF, McCarthy CG Clinical Science (London) 2023  
A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle Unger CA, Hope MC 3rd, Aladhami AK, Cotham WE, Socia CE, Rice BC, Clegg DJ, Velázquez KT, LaVoie HA, Hollis F, Enos RT Endocrinology 2023  
Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency Piroli GG, Manuel AM, McCain RS, Smith HH, Ozohanics O, Mellid S, Cox JH, Cotham WE, Walla MD, Cascón A, Ambrus A, Frizzell N Redox Biology 2023  
To err, K(IR)2 that is, on the side of vasodilation in aging Bernardino de Paula R, Wenceslau CF, McCarthy CG American Journal of Physiology - Heart and Circulatory Physiology 2023  
Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells Truex NL, Rondon A, Rössler SL, Hanna CC, Cho Y, Wang BY, Backlund CM, Lutz EA, Irvine DJ, Pentelute BL ACS Central Science 2023  
Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats Gorman-Sandler E, Robertson B, Crawford J, Wood G, Ramesh A, Arishe OO, Webb RC, Hollis F Neurobiology of Stress 2023  
Delayed cognitive impairments in a rat model of Gulf War Illness are stimulus-dependent Burzynski HE, Ayala KE, Frick MA, Dufala HA, Woodruff JL, Macht VA, Eberl BR, Hollis F, McQuail JA, Grillo CA, Fadel JR, Reagan LP Brain, Behavior, and Immunity 2023  
Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes Kokinos EK, Tsymbal SA, Galochkina AV, Bezlepkina SA, Nikolaeva JV, Vershinina SO, Shtro AA, Tatarskiy VV, Shtil AA, Broude EV, Roninson IB, Dukhinova M Viruses 2023  
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB Nucleic Acids Research 2023  
The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice Cao X, Nguyen V, Tsai J, Gao C, Tian Y, Zhang Y, Carver W, Kiaris H, Cui T, Tan W Molecular Metabolism 2023  
The Polypharmacological Effects of Cannabidiol Castillo-Arellano J, Canseco-Alba A, Cutler SJ, León F Molecules 2023  
Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification Saatci O, Akbulut O, Cetin M, Sikirzhytski V, Uner M, Lengerli D, O'Quinn EC, Romeo MJ, Caliskan B, Banoglu E, Aksoy S, Uner A, Sahin O Cell Death & Differentiation 2023  
RASSF1 is identified by transcriptome coordination analysis as a target of ATF4 Zhang Y, Huynh-Dam KT, Ding X, Sikirzhytski V, Lim CU, Broude E, Kiaris H FEBS Open Bio 2023  
Structural Basis for Variations in Polo-like Kinase 1 Conformation and Intracellular Stability Induced by ATP-Competitive and Novel Noncompetitive Abbapolin Inhibitors Chapagai D, Merhej G, McInnes C, Wyatt MD ACS Chemical Biology 2023  
One-Pot High-throughput Synthesis of N3-Substituted 5-Arylidene-2-Thiohydantoin Amides and Acids Whitely C, Li Y Tetrahedron Letters 2022  
Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis Gasparian A, Aksenova M, Oliver D, Levina E, Doran R, Lucius M, Piroli G, Oleinik N, Ogretmen B, Mythreye K, Frizzell N, Broude E, Wyatt MD, Shtutman M Molecular Biology of the Cell 2022  
Graphene-incorporated hyaluronic acid-based hydrogel as a controlled Senexin A delivery system Maturavongsadit P, Wu W, Fan J, Roninson IB, Cui T, Wang Q Biomaterials Translational 2022  
Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories Pilarzyk K, Porcher L, Capell WR, Burbano SD, Davis J, Fisher JL, Gorny N, Petrolle S, Kelly MP Aging Cell 2022  
A new fluorescent sensor mitoferrofluor indicates the presence of chelatable iron in polarized and depolarized mitochondria Kholmukhamedov A, Li L, Lindsey CC, Hu J, Nieminen AL, Takemoto K, Beeson GC, Beneker CM, McInnes C, Beeson CC, Lemasters JJ Journal of Biological Chemistry 2022  
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O'Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV Proceedings of the National Academy of Sciences of the United States of America 2022  
Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer Shonibare Z, Monavarian M, O'Connell K, Altomare D, Shelton A, Mehta S, Jaskula-Sztul R, Phaeton R, Starr MD, Whitaker R, Berchuck A, Nixon AB, Arend RC, Lee NY, Miller CR, Hempel N, Mythreye K Cell Reports 2022  
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance Tabury K, Monavarian M, Listik E, Shelton AK, Choi AS, Quintens R, Arend RC, Hempel N, Miller CR, Györrfy B, Mythreye K Life Science Alliance 2022  
Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma Chaurasiya ND, Leon F, Muhammad I, Tekwani BL Molecules 2022  
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2 Nguyen V, Zhang Y, Gao C, Cao X, Tian Y, Carver W, Kiaris H, Cui T, Tan W Cells 2022  
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers Horst B, Pradhan S, Chaudhary R, Listik E, Quintero-Macias L, Choi AS, Southard M, Liu Y, Whitaker R, Hempel N, Berchuck A, Nixon AB, Lee NY, Henis YI, Mythreye K Communications Biology 2022  
Surface Functionalization of Polymer Particles for Cell Targeting by Modifying Emulsifier Chemistry Isely C, Atube KJ, Cheung CV, Steege CF, Pellechia PJ, Gower RM ACS Applied Polymer Materials 2022  
Identification and Biosynthesis of Pro-Inflammatory Sulfonolipids from an Opportunistic Pathogen Chryseobacterium gleum Hou L, Tian HY, Wang L, Ferris ZE, Wang J, Cai M, Older EA, Raja MRK, Xue D, Sun W, Nagarkatti P, Nagarkatti M, Chen H, Fan D, Tang X, Li J ACS Chemical Biology 2022  
Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes Xue D, Older EA, Zhong Z, Shang Z, Chen N, Dittenhauser N, Hou L, Cai P, Walla MD, Dong SH, Tang X, Chen H, Nagarkatti P, Nagarkatti M, Li YX, Li J Nature Communications 2022  
Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer Assidicky R, Tokat UM, Tarman IO, Saatci O, Ersan PG, Raza U, Ogul H, Riazalhosseini Y, Can T, Sahin O Breast Cancer Research and Treatment 2022  
GABA(B) receptors in prelimbic cortex and basolateral amygdala differentially influence intertemporal decision making and decline with age Hernandez CM, McQuail JA, Ten Eyck TW, Wheeler AR, Labiste CC, Setlow B, Bizon JL Neuropharmacology 2022  
A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics Zhang L, Cheng C, Li J, Wang L, Chumanevich AA, Porter DC, Mindich A, Gorbunova S, Roninson IB, Chen M, McInnes C Journal of Medicinal Chemistry 2022  
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers Cicek E, Circir A, Oyken M, Akbulut Caliskan O, Dioken DN, Guntekin Ergun S, Cetin-Atalay R, Sapmaz A, Ovaa H, Sahin O, Erson-Bensan AE Oncogene 2022  
Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q Park I, Phan TM, Fang J Cancers (Basel)

Heterogeneous Myeloid Cells in Tumors Dou A, Fang J Cancers (Basel) 2021  
Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells Chapagai D, Ramamoorthy G, Varghese J, Nurmemmedov E, McInnes C, Wyatt MD Journal of Medicinal Chemistry 2021  
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration Jhanji M, Rao CN, Massey JC, Hope MC 3rd, Zhou X, Keene CD, Ma T, Wyatt MD, Stewart JA, Sajish M Nature Communications 2022  
Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE Craig SN, Baxter M, Chapagai D, Stafford JM, Nurmemmedov E, Altomare D, Wyatt MD, McInnes C European Journal of Medicinal Chemistry 2022  
Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies Saatci O, Huynh-Dam KT, Sahin O Journal of Molecular Medicine (Berlin, Germany) 2021  
Mercapto-functionalized polyhedral oligomeric silsesquioxane as a soluble support for the synthesis of peptide thioesters Perry K, Sui B, Li Y Tetrahedron Letters 2021  
Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis Hohn J, Tan W, Carver A, Barrett H, Carver W Cells 2021  
Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain Zhang Y, Lim CU, Sikirzhytski V, Naderi A, Chatzistamou I, Kiaris H Disease Models & Mechanisms 2021  
Attenuated NMDAR signaling on fast-spiking interneurons in prefrontal cortex contributes to age-related decline of cognitive flexibility McQuail JA, Beas BS, Kelly KB, Hernandez CM 3rd, Bizon JL, Frazier CJ Neuropharmacology 2021  
Genomic variation in captive deer mouse (Peromyscus maniculatus) populations Lucius MD, Ji H, Altomare D, Doran R, Torkian B, Havighorst A, Kaza V, Zhang Y, Gasparian AV, Magagnoli J, Shankar V, Shtutman M, Kiaris H BMC Genomics 2021  
Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice Cao X, Tian Y, Nguyen V, Zhang Y, Gao C, Yin R, Carver W, Fan D, Albrecht H, Cui T, Tan W FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021  
Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation Ukhueduan B, Chukwurah E, Patel RC The international journal of biochemistry & cell biology 2021  
Macrophage tumor necrosis factor-alpha deletion does not protect against obesity-associated metabolic dysfunction Aladhami AK, Unger CA, Ennis SL, Altomare D, Ji H, Hope MC 3rd, Velázquez KT, Enos RT FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021  
A strategy for the identification of paracrine regulators of cancer cell migration Chavez B, Farmaki E, Zhang Y, Altomare D, Hao J, Soltnamohammadi E, Shtutman M, Chatzistamou I, Kiaris H Clinical and experimental pharmacology & physiology 2020  
Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2020  
Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice Jeong HW, Choi RH, Koh HJ Biochemical and biophysical research communications 2021  
Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling Vaughn LS, Chukwurah E, Patel RC The Biochemical journal 2021  
The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs Sharko AC, Lim CU, McDermott MSJ, Hennes C, Philavong KP, Aiken T, Tatarskiy VV, Roninson IB, Broude EV Cells 2021  
Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer Siddiqui MA, Gollavilli PN, Ramesh V, Parma B, Schwab A, Vazakidou ME, Natesan R, Saatci O, Rapa I, Bironzo P, Schuhwerk H, Asangani IA, Sahin O, Volante M, Ceppi P British journal of cancer 2021  
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly Cui BC, Sikirzhytski V, Aksenova M, Lucius MD, Levon GH, Mack ZT, Pollack C, Odhiambo D, Broude E, Lizarraga SB, Wyatt MD, Shtutman M Biochemical pharmacology 2020  
Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress Ackerson SM, Gable CI, Stewart JA Cell cycle (Georgetown, Tex.) 2020  
Fabrication of biodegradable particles with tunable morphologies by the addition of resveratrol to oil in water emulsions Isely C, Stevens AC, Tate GL, Monnier JR, Gower RM International journal of pharmaceutics 2020  
Towards resolving the enigma of the dichotomy of resveratrol: cis and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation Jhanji M, Rao CN, Sajish M GeroScience 2020  
Carrier-Free Nanoassembly of Curcumin-Erlotinib Conjugate for Cancer Targeted Therapy Cheng C, Sui B, Wang M, Hu X, Shi S, Xu P Advanced healthcare materials 2020  
Redox-Sensitive Nanocomplex for Targeted Delivery of Melittin Cheng B, Xu P Toxins 2020  
Enhanced Photothermal Therapy through the In Situ Activation of a Temperature and Redox Dual-Sensitive Nanoreservoir of Triptolide Liu HJ, Wang M, Hu X, Shi S, Xu P Small (Weinheim an der Bergstrasse, Germany) 2020  
Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts Wu W, Wang C, Zang H, Qi L, Azhar M, Nagarkatti M, Nagarkatti P, Cai G, Weiser-Evans MCM, Cui T Arteriosclerosis, thrombosis, and vascular biology 2020  
Modulation of adipocyte size and fat pad weight via resveratrol releasing scaffolds implanted into the epididymal adipose tissue Murphy KP, Hendley MA, Patterson AT, Hall HE, Carter GJ, Isely C, Gower RM Journal of biomedical materials research 2020  
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation Avcilar-Kucukgoze I, Gamper H, Polte C, Ignatova Z, Kraetzner R, Shtutman M, Hou YM, Dong DW, Kashina A Cell chemical biology 2020  
Regulation of stress-induced hematopoiesis Anderson GA, Rodriguez M, Kathrein KL Current opinion in hematology 2020  
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies McQuail JA, Dunn AR, Stern Y, Barnes CA, Kempermann G, Rapp PR, Kaczorowski CC, Foster TC Frontiers in aging neuroscience 2020  
Scaffold Implant Into the Epididymal Adipose Tissue Protects Mice From High Fat Diet Induced Ectopic Lipid Accumulation and Hyperinsulinemia Hendley MA, Isely C, Murphy KP, Hall HE, Annamalai P, Gower RM Frontiers in bioengineering and biotechnology 2020  
Coordination Analysis of Gene Expression Points to the Relative Impact of Different Regulators During Endoplasmic Reticulum Stress Zhang Y, Lucius MD, Altomare D, Havighorst A, Farmaki E, Chatzistamou I, Shtutman M, Kiaris H DNA and cell biology 2019  
Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy Mohammed AD, Khan MAW, Chatzistamou I, Chamseddine D, Williams-Kang K, Perry M, Enos R, Murphy A, Gomez G, Aladhami A, Oskeritzian CA, Jolly A, Chang Y, He S, Pan Z, Kubinak JL Frontiers in immunology 2019  
CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition  McDermott MSJ, Sharko AC, Munie J, Kassler S, Melendez T, Lim CU, Broude EV Cells 2020  tag 1, tag2
A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate Akbulut O, Lengerli D, Saatci O, Duman E, Seker UOS, Isik A, Akyol A, Caliskan B, Banoglu E, Sahin O Molecular Cancer Therapeutics 2020   
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer Saatci O, Kaymak A, Raza U, Ersan PG, Akbulut O, Banister CE, Sikirzhytski V, Tokat UM, Aykut G, Ansari SA, Dogan HT, Dogan M, Jandaghi P, Isik A, Gundogdu F, Kosemehmetoglu K, Disdar O, Aksoy S, Akyol A, Uner A, Buckhaults PJ, Riazalhosseini Y, Sahin O Nature Communications 2020   
TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy Choi RH, McConahay A, Silvestre JG, Moriscot AS, Carson JA, Koh HJ The FASEB Journal 2019  
Role of transcription-regulating kinase CDK8 in colon cancer metastasis Liang J, Chen M, Broude EV, Roninson IB Oncotarget 2019  
Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles Cheng B, Gao F, Maissy E, Xu P Acta Biomaterialia 2019  
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein Alam A, Kowal J, Broude E, Roninson I, Locher KP Science 2019   
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization  Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N Molecular & Cellular Proteomics 2019   
Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association Wang Y, Brady KS, Caiello BP, Ackerson SM, Stewart JA Life Science Alliance 2019   
Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation Yanez M, Jhanji M, Murphy K, Gower RM, Sajish M, Jabbarzadeh E Scientific Reports 2019   
Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice Oza M, Becker W, Gummadidala PM, Dias T, Omebeyinje MH, Chen L, Mitra C, Jesmin R, Chakraborty P, Sajish M, Hofseth LJ, Banerjee K, Wang Q, Moeller PDR, Nagarkatti M, Nagarkatti P, Chanda A Scientific Reports 2019   
Identifying Cancers Impacted by CDK8/19 Roninson IB, Gyorffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV Cells 2019   
HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression Hosseinipour M, Wan F, Altomare D, Creek KE, Pirisi L Virology 2019  
Development of microparticles for controlled release of resveratrol to adipose tissue and the impact of drug loading on particle morphology and drug release Isely C, Hendley MA, Murphy KP, Kader S, Annamalai P, Jabbari E, Gower RM International Journal of Pharmaceutics 2019  
Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer Uretmen Kagiali ZC, Sanal E, Karayel O, Polat AN, Saatci O, Ersan PG, Trappe K, Renard BY, Onder TT, Tuncbag N, Sahin O, Ozlu N Molecular & Cellular Proteomics 2019  
The host response to poly(lactide-co-glycolide) scaffolds protects mice from diet induced obesity and glucose intolerance Hendley MA, Murphy KP, Isely C, Struckman HL, Annamalai P, Gower RM Biomaterials 2019  
Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay Li J, Ji H, Porter DC, Broude EV, Roninson IB, Chen M Cells 2019  
Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition Chen M, Li J, Liang J, Thompson ZS, Kathrein K, Broude EV, Roninson IB Cells 2019  
Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers Siddiqui A, Gollavilli PN, Schwab A, Vazakidou ME, Ersan PG, Ramakrishnan M, Pluim D, Coggins S, Saatci O, Annaratone L, Hm Schellens J, Kim B, Asangani IA, Rasheed SAK, Marchio C, Sahin O, Ceppi P Cell Death & Differentiation 2019  
Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M Journal of Neuroimmune Pharmacology 2019  
The Meisenheimer Complex as a paradigm in drug discovery: reversible covalent inhibition through C67 of the ATP binding site of PLK1 Pearson RJ, Blake DG, Mezna M, Fischer PM, Westwood NJ, McInnes C Cell Chemical Biology 2018  
Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review Benedict C, Grillo CA Frontiers in Neuroscience 2018  
hnRNPs binding to the axonal localization motifs of Nrn1 and HMGB1 mRNAs define growth-associated RNA regulons Lee SJ, Oses-Prieto JA, Kawaguchi R, Sahoo PK, Kar AN, Rozenbaum M, Oliver D, Chand S, Ji H, Shtutman M, Miller-Randolph S, Taylor RJ, Fainzilber M, Coppola G, Burlingame AL, Twiss JL Molecular & Cellular Proteomics 2018  
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB Cancer Research 2018  
Impact of nutrition on inflammation, taupathy, and behavioral outcomes from chronic traumatic encephalopathy Yu J, Zhu H, Taheri S, Mondy W, Perry S, Kindy MS Journal of Neuroinflammation 2018  
Deoxycholate fractionation of fibronectin (FN) and biotinylation assay to measure recycled FN fibrils in epithelial cells Varadaraj A, Magdaleno C, Mythreye K Bio-protocol 2018  
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K Oncogene 2018  
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K Cancer Research 2018  
Dually modified transmembrane proteoglycans in development and disease Jenkins LM, Horst B, Lancaster CL, Mythreye K Cytokine & Growth Factor Reviews 2018  
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1 Alam A, Kung R, Kowal J, Mcleod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP Proceedings of the National Academy of Sciences of the United States of America 2018  
Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival

2018 Pilot Project Publication

Chukwurah E, Patel RC Scientific Reports 2018  
Dually modified transmembrane proteoglycans in development and disease Jenkins LM, Horst B, Lancaster CL, Mythreye K Cytokine & Growth Factor Reviews 2017  
Tris (1, 3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos Dasgupta S, Vliet SM, Kupsco A, Leet JK, Altomare D, Volz DC PeerJ 2017  
Succination of Protein Disulfide Isomerase Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N Antioxidants & Redox Signaling 2017  
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB Proceedings of the National Academy of Sciences of the United States of America


TGF-β triggers rapid fibrillogenesis via a novel TβRIIdependent fibronectin-trafficking mechanism Varadaraj A, Jenkins LM, Singh P, Chanda A, Snider J, Lee NY, Amsalem-Zafran AR, Ehrlich M, Henis YI, Mythreye K Molecular Biology of the Cell 2017  
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Pena E, Shtutman M Scientific Reports 2017  
Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and dysregulated autophagy Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY Oncotarget 2017  
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Gyorffy B, Roninson IB, Broude EV Oncotarget 2017  
Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure Vassoler FM, Oliver DJ, Wyse C, Blau A, Shtutman M, Turner JR, Byrnes EM Neuropharmacology 2017  
Cellular Model of p21-Induced Senescence Shtutman M, Chang BD, Schools GP, Broude EV Methods in Molecular Biology 2017  
IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis Zhang Y, Davis C, Shah S , Hughes D, Ryan JC, Altomare D, Pena MM Molecular Carcinogenesis 2017  
Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1) Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Domling AS, Shtutman M, Groves MR Acta Crystallographica Section F 2017  
ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element

2017 Pilot Project Publication

Chukwurah E, Handy I, Patel RC Biochemical Journal 2017  
Intranasal insulin in Alzheimer's Disease: Food for thought

2017 Pilot Project Publication

Chapman CD, Schiöth HB, Grillo C, Benedict C Neuropharmacology 2017  
Tribbles 3 regulates protein turnover in mouse skeletal muscle

2017 Pilot Project Publication

Choi RH, McConahay A, Jeong H, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ Biochemical and Biophysical Research Communications 2017  
Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K Journal of Biological Chemistry 2016  
PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain Hegde S, Ji H, Oliver D, Patel NS, Poupore N, Shtutman M, Kelly MP Neuroscience 2016  
Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY Molecular Cell 2016  
A novel double-negative feedback loop between miR-489 and the HER2-SHP2- MAPK signaling axis regulates breast cancer cell proliferation and tumor growth Patel Y, Shah N, Lee JS, Markoutsa E, Jie C, Liu S, Botbyl R, Reisman D, Xu P, Chen H Oncotarget 2016  
Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy Cheng B, He H, Huang T, Berr SS, He J, Fan D, Zhang J, Xu P Journal of Biomedical Nanotechnology 2016  
Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ Biochemical and Biophysical Research Communications 2016  
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N Molecular & Cellular Proteomics 2016  
A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking

2016 Pilot Project Publication

White S, Ortinski P, Friedman SH, Zhang L, Neve R, Kalb RG, Schmidt HD, Pierce RC Neuropsychopharmacology 2016  
Behavioral History of Withdrawal Influences Regulation of Cocaine Seeking by Glutamate Reuptake

2016 Pilot Project Publication

Zhou L, Anderson H, Arreola AC, Turner J, Ortinski PI PLOS One 2016  
Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers Rai R, Zhang F, Colavita K, Leu NA, Kurosaka S, Kumar A, Birnbaum MD, Gyorffy B, Dong DW, Shtutman M, Kashina A Oncogene 2015  
Cancer cell-selective killing polymer/copper combination He H, Altomare D, Ozer U, Xu H, Creek K, Chen H, Xu P Biomaterials Science 2015  
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K Neoplasia 2015  
Purification of high-quality RNA from synthetic polyethylene glycol-based hydrogels Gasparian A, Daneshian L, Ji H, Jabbari E, Shtutman M Analytical Biochemistry 2015  
Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine Gomez AM, Altomare D, Sun WL, Midde NM, Ji H, Shtutman M, Turner JR, Creek KE, Zhu J. The International Journal of Neuropsychopharmacology 2015  
Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY Journal of Biological Chemistry 2015  
Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M Oncotarget 2015  
Dual secured nano-melittin for the safe and effective eradication of cancer cells. Journal of materials chemistry Bei C, Bindu T, Remant KC, Peisheng X Journal of Materials Chemistry B 2015  
The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes Tanis RM, Piroli GG, Day SD, Frizzell N Biochimica et Biophysica Acta 2015  
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer Broude EV, Gyorffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB Current Cancer Drug Targets 2015  
The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility

2015 Pilot Project Publication

Provence A, Malysz J, Petkov, GV Journal of Pharmacology and Experimental Therapeutics 2015  
Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery He H, Cattran AW, Nguyen T, Nieminen AL, Xu P Biomaterials 2014  
Identification of protein succination as a novel modification of tubulin Piroli GG, Manuel AM, Walla MD, Jepson MJ, Brock JW, Rajesh MP, Tanis RM, Cotham WE, Frizzell N Biochemical Journal 2014  







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