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College of Pharmacy

Scientist in a lab

SmartState Center for Translational Cancer Therapeutics

The SmartState Center for Translational Cancer Therapeutics at the University of South Carolina seeks to discover new drug targets and develop novel drugs and approaches for cancer treatment.


The SmartState Center for Translational Cancer Therapeutics at the College of Pharmacy was established in 2011 under the direction of Igor Roninson through a state-funded endowed chair program.

Roninson is internationally recognized for cancer research, including his study of multi-drug resistance in cancer and chemotherapy-induced senescence in tumor cells. The Center for Translational Cancer Therapy provides a platform for the discovery and development of cancer drugs.

Principal Research Interests

Our principal research interests include:

  • Developing personalized cancer therapy based on target and drug discovery through functional genomics and chemical genomics
  • Chemical genomics of tumor microenvironment
  • Mechanisms and pharmacological modulation of a damage-inducible signal transduction pathway implicated in cancer
  • Maintenance of chromosome stability by homologous recombination (HR) DNA repair mechanisms and cancer progression
  • Developing combinatorial approaches of newly discovered drugs with existing therapies for breast and prostate cancer

Challenge the conventional. Create the exceptional. No Limits.